dinsdag 30 september 2014

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Transformations: Women, Gender, And Psychology, by Mary Crawford

Part 1. INTRODUCTION 1. Paving the Way Part 2. GENDER IN SOCIAL CONTEXT 2. Gender, Status, and Power 3. Images of Women 4. The Meanings of Difference Part 3. GENDER AND DEVELOPMENT 5. Sex, Gender and Bodies 6. Gendered Identities: Childhood And Adolescence 7. In a Woman's Body Part 4.

  • Sales Rank: #492942 in Books
  • Published on: 2005-07
  • Ingredients: Example Ingredients
  • Original language: English
  • Number of items: 1
  • Dimensions: 7.28" h x .91" w x 7.28" l,
  • Binding: Paperback
  • 576 pages

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0 of 0 people found the following review helpful.
Five Stars
By Jean Kops
The book is in very good shape and the price was reasonable

0 of 0 people found the following review helpful.
Five Stars
By Angelica G.
Great book

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vrijdag 26 september 2014

[K122.Ebook] Download American Commercial Banks in Corporate Finance, 1929-1941: A Study in Banking Concentrations (Financial Sector of the American Economy)B

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Through a systematic study of historical data, this book argues that a small group of New York banks, by means of term loans and working in close collaboration with their affiliated life insurance companies, exerted a strong influence over the supply of money and credit, and thus over the entire economy throughout the years of the depression. The book analyzes the growth of term loans under the depression, the concentration of the loans in a handful of powerful New York banks, the interplay between these banks and large life insurance companies in the capital market, and the resulting economic consequences. It also details the changes that took place in the leadership within the financial heirarchy during the depression: the J. D.


Rockefeller interests replaced the Morgan-First National interests as the country's dominant financial power - a change that has escaped previous scholarly notice."

  • Published on: 2012-11-12
  • Released on: 2012-11-12
  • Format: Kindle eBook

Review
...he has done a tour de force of source work. He has mined the financial periodicals and other sources to an extraordinary degree. EH.Net .

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maandag 22 september 2014

[V140.Ebook] Ebook Free Deconstructing Organized Crime: An Historical and Theoretical Study, by Joseph L. Albini, Jeffrey Scott McIllwain

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Deconstructing Organized Crime: An Historical and Theoretical Study, by Joseph L. Albini, Jeffrey Scott McIllwain

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Deconstructing Organized Crime: An Historical and Theoretical Study, by Joseph L. Albini, Jeffrey Scott McIllwain

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Deconstructing Organized Crime: An Historical and Theoretical Study, by Joseph L. Albini, Jeffrey Scott McIllwain

What is organized crime? There have been many answers over the decades from scholars, governments, the media, pop culture and criminals themselves. These answers cumulatively created a "Mafia Mystique" that dominated discourse until after the Cold War, when transnational organized crime emerged as a pronounced, if nebulous, threat to global security and stability. The authors focus both on the American experience that dominated organized crime scholarship in the second half of the 20th century and on the more recent global scene. Case studies show that organized crime is best understood not as a series of famous gangsters and events but as a structure of everyday life formed by numerous political, social, economic and anthropological variables.

  • Sales Rank: #971800 in Books
  • Brand: Brand: McFarland
  • Published on: 2012-09-11
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.90" h x .70" w x 5.90" l, .65 pounds
  • Binding: Paperback
  • 217 pages
Features
  • Used Book in Good Condition

Review
"A fascinating historical look at the mythology and reality of organized crime past and present. A scholarly inquiry into the ways public perception influences crime policy and law enforcement." --Jay S. Albanese, Virginia Commonwealth University and former Chief of the International Center, National Institute of Justice

"A criminological tour-de-force by two dedicated and respected scholars that bridges the late 20th century with the 21st century in describing the intellectual effort to explain the changing nature of organized crime." --Frank Hagan, Mercyhurst College

"Informative overview...detailed.... Rigorous and highly readable, this is an important contribution to the field of criminology. Highly recommended" --Choice

About the Author
Joseph L. Albini is a professor emeritus in the department of sociology at Wayne State University. He has offered lectures and written numerous articles over six decades on the history of organized crime. He lives in Las Vegas, Nevada.

Jeffrey Scott McIllwain is an associate professor in the Criminal Justice and Criminology Program and co-director of the Graduate Program in Homeland Security at San Diego State University. He lives in La Mesa, California.

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1 of 4 people found the following review helpful.
Minus a Star for Grammar Error on Cover
By e. siran
This book is interesting, but it's nothing spectacular. I have read better written, more interesting books on the subject (and they were written from an academic perspective as well). I would give the book 4 stars, but there is a grammatical error on the cover -- yes, on the cover! The title is "Deconstructing Organized Crime: An Historical and Theoretical Study." "An" is incorrect. It should be "A." This is a little, nitpicky thing, but when both authors are professors, I expect someone to catch this.

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[I530.Ebook] Free PDF Lurecraft: How to Make Plugs, Spinners, Spoons, and Jigs to Catch More Fish, by Russ Mohney

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Lurecraft: How to Make Plugs, Spinners, Spoons, and Jigs to Catch More Fish, by Russ Mohney

Make your own lures to beat the high cost of tackle and develop a creative and satisfying hobby. Learn how to craft fishing lures that are more effective than those you buy, with detailed instructions and hundreds of superb illustrations. Covers plugs, surface lures and poppers, spinners, spoons and buzzers, jigs, trout lures, steelhead and salmon lures, and lures for big water fishing. Includes a step-by-step guide to carving, painting and finishing lures, along with a colorful photo gallery of hand-carved lures.

  • Sales Rank: #217374 in Books
  • Published on: 2013-06-01
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.75" h x .58" w x 7.75" l, 1.74 pounds
  • Binding: Paperback
  • 304 pages

Review
"Packs in details woodworkers will find essential to crafting effective lures, and is a pick for both crafts and sports shelves alike. . . . a 'must' for any fisherman or woodworker." --California Bookwatch, The Crafts Shelf, October 2013

From the Back Cover
Make Your Own Lures and Start Catching Fish To catch a fish with a lure that you made yourself is one of the most satisfying experiences an angler can have. This book explains, with detailed instructions and hundreds of superb illustrations, how to craft fishing lures that are more effective than those you buy. By making your own lures you'll beat the high cost of tackle, while developing a creative and satisfying hobby that requires just a few tools and easily obtained materials. Lurecraft shows how to design lures for local waters, so they're better suited to regional conditions and catch more fish. The author explains the science of fish attraction-why lures appeal to fish-and covers tools, materials, and basic techniques for working with wood, metal, wire, and paint. You'll learn to build plugs, surface lures and poppers, spinners, spoons and buzzers, jigs, trout lures, steelhead and salmon lures, and lures for big water fishing. This classic book, newly updated for the twenty-first century fisherman, includes an illuminating step-by-step guide to carving, painting and finishing lures, along with a colorful photo gallery of hand-carved lures based on the author's designs. Make your own lures to beat the high cost of tackle and catch more fish! - Step-by-step guide to carving, painting and finishing lures - The science of attraction--what makes lures appeal to fish? - Advice on tools, techniques and materials. Hundreds of superb diagrams and illustrations - Colorful gallery of finished hand-crafted lures

About the Author
Russ Mohney was a freelance writer on outdoor subjects. Trained as a naturalist, he specialized in fish behavior, which led to his becoming an ardent angler and lure maker. He had published over 300 articles in outdoor magazines, as well as eight books on the outdoors including, Why Wild Edibles?, Master Backpacker, and Make It and Take It. He had fished over most of the West, as well as Alaska, Asia, and South America. He wrote and broadcasted a daily program on the outdoors for radio stations in Centralia, Washington.

Most helpful customer reviews

4 of 4 people found the following review helpful.
Lurecraft: How to make plugs, Spinners, Spoons and Jigs
By Clay breaker
Excellent book. it gives many insights to lure building. I would recommend it to anyone interested in lure making. Also, many designs are offered.

1 of 1 people found the following review helpful.
He likes it
By jtony
Bought this for my boyfriend he says its much better than many other books he has looked at and almost purchased. Colorful photos, descriptive and easy to follow.

1 of 1 people found the following review helpful.
Not much about jig fishing so I'm disappointed!
By Mr. White
The book sounds like a good book for other lures but didn't see much mention of jig fishing which is the advent of the sport! :(

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zondag 21 september 2014

[C812.Ebook] Fee Download Curren's Math for Meds: Dosages and Solutions, 11th Edition, by Anna M. Curren, Margaret H. Witt

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Curren's Math for Meds: Dosages and Solutions, 11th Edition, by Anna M. Curren, Margaret H. Witt

Now in its 11th Edition, CURREN'S MATH FOR MEDS: DOSAGES AND SOLUTIONS is the preeminent authority on drug dosage calculations, ratio and proportion, and medication safety. Often imitated yet never equaled, the book delivers proven material with a concisely organized approach that takes you from basic to complex using a building block approach. . Coverage begins with chapters designed to review and confirm basic math principles. Common drug measures are introducted next, followed by detailed lessons on medication labels and dosage calculations. Instructions on body weight and body surface area, intravenous calculations, and pediatric medication calculations follow. This new edition of CURREN'S MATH FOR MEDS: DOSAGES AND SOLUTIONS features full-color photos of drug labels and syringes, as well as hundreds of examples, practice problems, self-test questions, and more for developing learners into safe and effective practitioners. Deliver your course with help from the master, Anna Curren, and CURREN'S MATH FOR MEDS: DOSAGES AND SOLUTIONS, 11th Edition--the only calculations text to reach more than a million learners!

  • Sales Rank: #49774 in Books
  • Published on: 2014
  • Original language: English
  • Number of items: 1
  • Dimensions: 10.80" h x .60" w x 8.40" l, 1.70 pounds
  • Binding: Paperback
  • 384 pages

Review
SECTION 1: REFRESHER MATH. 1. Relative Value, Addition and Subtraction of Decimals. 2. Multiplication and Division of Decimals. 3. Solving Common Fraction Equations. SECTION 2: INTRODUCTION TO DRUG MEASURES. 4. Metric, International (SI) System. 5. Unit, Percentage, Milliequivalent, Ratio,and HouseholdMeasures. SECTION 3: CALCULATING DOSAGES FROM MEDICATION LABELS AND SYRINGE CALIBRATIONS, AND SAFE MEDICATION ADMINISTRATION. 6. Oral Medication Labels. 7. Safe Medication Administration. 8. Hypodermic Syringe Measurement. 9. Reading Parenteral Medication Labels. 10. Reconstitution of Powdered Drugs. 11. Measuring Insulin Dosages. SECTION 4: DOSAGE CALCULATIONS. 12. Ratio and Proportion. 13. Dimensional Analysis/Units Conversion. 14. Formula Method. SECTION 5: DOSAGE CALCULATION FROM BODY WEIGHT AND BODY SURFACE AREA. 15. Adult and Pediatric Dosages Based on Body Weight. 16. Adult and Pediatric Dosages Based on Body Surface Area. SECTION 6: INTRAVENOUS CALCULATIONS. 17. Introduction to IV Therapy. 18. IV Flow Rate Calculation. 19. Calculating IV Infusion and Completion Times. 20. IV Medication and Titration Calculations. 21. Heparin Infusion Calculations. SECTION 7: PEDIATRIC MEDICATION CALCULATIONS. 22. Pediatric Oral and Parenteral Medications. 23. Pediatric Intravenous Medications.

About the Author
Anna Curren has been writing inspired clinical textbooks for more than 40 years. A nurse and former Associate Professor at California's Long Beach City College, she first wrote this text when the one she was using bore no resemblance to her students' clinical needs. Her graduate degree in instructional design, along with many student and instructor reviews, helped her create what is now the most adopted text on the subject. Also a successful entrepreneur, Ms. Curren founded Wallcur, Inc., a company which produces instructional products, including Injecta-Pad, Practi-Amp, Practi-Insulin Training Pack, and other learning resources. Ms. Curren also wrote the best-selling Dimensional Analysis For Meds, also by Cengage Learning.

Margaret Witt is a nurse and physical therapist with more than 26 years of experience, including in the operating room and as a flight nurse. A retired Major in the US Air Force, Dr. Witt spent many years instructing and evaluating flight nurses, as well as writing, reviewing, and enforcing nursing regulations. She is currently Head and Coordinator of the Rehabilitation Department at Spokane Veterans Administration Hospital in Washington. Hand-picked by Anna Curren to lead future editions of CURREN'S MATH FOR MEDS: DOSAGES AND SOLUTIONS, Dr. Witt contributes unrivaled professional experience and training to this always popular book.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Great Book for Nursing Class
By denise savona
Curren's Math for Meds: Dosages and Solutions, 11th Edition I purchased this book used. It was in really good condition and cost a fraction of the price in the school book store. My daughter is in college for Registered Nursing and this book is a great help in learning to calculate medication dosages. Being a nurse myself I live that it has full colored photos and lots of practice problems.

0 of 0 people found the following review helpful.
This book was recommended for my Pharmacology class but i have only used ...
By Julissa
This book was recommended for my Pharmacology class but i have only used the book twice. I am very good when it comes to math so i didn't need the book, but i will say that it is very detailed with the steps required to do dosage calculations.
If you are a math whiz then then it is an unnecessary buy but if you struggle with math then it is recommended that you buy this book.

0 of 0 people found the following review helpful.
Awesome review for an RN returning to the workforce.
By Lucinda
Awesome review for an RN returning to the workforce. It covers all the meds calculations that a nurse could possibly come across, from neonatal to geriatric, from oncology to ICU. I can also see where a nursing student would benefit. Haven't used the online portion simply because the text is so comprehensive.

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donderdag 18 september 2014

[D238.Ebook] Free PDF Redoble por Rancas, by Manuel Scorza

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Redoble por Rancas, by Manuel Scorza

First published in 1970, DRUMS FOR RANCAS was an immediate success in Spain and Latin America. Readers were captured by the breathtaking story of the 1962 Peruvian Andean peasants' struggle to keep their land. DRUMS FOR RANCAS has been translated into 25 languages .

  • Sales Rank: #2773190 in Books
  • Published on: 1997-11-01
  • Released on: 1997-11-01
  • Original language: Spanish
  • Number of items: 2
  • Dimensions: 7.74" h x .45" w x 5.18" l,
  • Binding: Paperback
  • 237 pages

Review
El poeta, narrador y editor peruano Manuel Scorza (1928-1983) dejo sin desmentir afirmaciones erroneas sobre su biografia e incluso contribuyo a la confusion informativa alrededor de su persona. Como ocurre tambien con buena parte de su obra, su concepcion de la autobiografia constituye otra forma de creacion en la que realidad y ficcion se hallan intimamente relacionadas. A pesar de que la produccion literaria de Manuel Scorza tuvo como centro vital, como tema unico e indiscutible, a su pais natal, Peru, su labor fue mas reconocida fuera de esas fronteras, y ""Redoble por Rancas"" tuvo un fulgurante exito europeo. La novela denuncia explicitamente los abusos sufridos por las comunidades campesinas de los Andes Centrales, de mayoria indigena, y su lucha contra la explotacion y la injusticia. Sin embargo, aunque la obra de Scorza responde a una hermeneutica que dialoga con la tradicion literaria peruana, representada por el indigenismo, trasciende sus limites y convenciones, y huye de esa etiqueta en un proceso constante y paulatino que se mueve en dos niveles. Uno historico real y otro ficcional, que desde un enfoque mitologico y fantastico tiene como funcion constituir una aclaracion de la realidad. --Los editores

Language Notes
Text: Spanish

Most helpful customer reviews

5 of 5 people found the following review helpful.
Scorza, a formidable Latin American author
By O. M. Suarez
Redoble por Rancas is part of the pentalogy of novels written by Scorza, that constitutes along with La Danza Inmovil his immortal legacy to Latin American literature. Rancas, that humble village in the middle of Peru is just a metaphore for the underprivileged all over Latin America. The abuses of the dominant elite, the absurdity of this oppression are challenged against all hope by the indigenous peasants. Behind the inevitable humor is a fierce criticism of the landowners, the big corporations, and the complicity of corrupt local authorities. It is the brutality of the repression that brings the reader to think of the immense tenderness that Scorza uses to paint his characters. However, this book cannot be read alone. You must try to get the other four: El Cantar de Agapito Robles, Garabombo El Invisible (my favorite), El Jinete Insomne, y La Tumba del Relampago.

1 of 1 people found the following review helpful.
A great story with rich quechua heritage
By Umaphuyu
I think this book successfully portrays the abuses committed by international corporations in the forgotten Andean region. The cruelty and abuses of the mining company as well as of the government towards the indigenous farmers of Rancas contrasts the witting and funny descriptions of events that may seem small but have a greater significance to the development of the story. The author does a great job in narrating a true story mixed with the magical realism style of Latin American writers. This is the first book I read from this author and I am truly happy I picked this book to read because I have learned that injustice and abuses towards the indigenous people of South America have not stopped since the Spanish first arrived there. This book really transported me into the story and made me more aware of the clash between the Inca and Spanish legacy in south America. It is time that the prejudices and wrong conceptions left by the Spanish are obliterated from south America so that they can all solve their problems together. I love this book. I highly recommend it!!

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dinsdag 16 september 2014

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  • Sales Rank: #4671540 in Books
  • Published on: 2012
  • Format: Laser printed
  • Binding: Ring-bound
  • 130 pages

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maandag 15 september 2014

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The Gene: An Intimate History, by Siddhartha Mukherjee

THE #1 NEW YORK TIMES BESTSELLER

From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?

Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Throughout the narrative, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—cuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

As The New Yorker said of The Emperor of All Maladies, “It’s hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion…An extraordinary achievement.” Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or “write” the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.

  • Sales Rank: #5142 in eBooks
  • Published on: 2016-05-17
  • Released on: 2016-05-17
  • Format: Kindle eBook

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188 of 201 people found the following review helpful.
"We used to think our future was in the stars. Now we know it's in our genes."
By Ash Jogalekar
Genetics is humanity and life writ large, and this book on the gene by physician and writer Siddhartha Mukherjee paints on a canvas as large as life itself. It deals with both the history of genetics and its applications in health and disease. It shows us that studying the gene not only holds the potential to transform the treatment of human disease and to feed the world’s burgeoning population, but promises to provide a window into life’s deepest secrets and into our very identity as human beings.

The volume benefits from Mukherjee’s elegant literary style, novelist’s eye for character sketches and expansive feel for human history. While there is ample explanation of the science, the focus is really on the brilliant human beings who made it all possible. The author’s own troubling family history of mental illness serves as a backdrop and keeps on rearing its head like a looming, unresolved question. The story begins with a trip to an asylum to see his troubled cousin; two of his uncles have also suffered from various "unravelings of the mind". This burden of personal inheritance sets the stage for many of the questions about nature, nurture and destiny asked in the pages that follow.

The book can roughly be divided into two parts. The first part is a sweeping and vivid history of genetics. The second half is a meditation on what studying the gene means for human biology and medicine.

The account is more or less chronological and this approach naturally serves the historical portion well. Mukherjee does a commendable job shedding light on the signal historical achievements of the men and women who deciphered the secret of life. Kicking off from the Greeks’ nebulous but intriguing ideas on heredity, the book settles on the genetics pioneer Gregor Mendel. Mendel was an abbot in a little known town in Central Europe whose pioneering experiments on pea plants provided the first window into the gene and evolution. He discovered that discrete traits could be transmitted in statistically predictable ways from one generation to next. Darwin came tantalizingly close to discovering Mendel’s ideas (the two were contemporaries), but inheritance was one of the few things he got wrong. Instead, a triumvirate of scientists rediscovered Mendel’s work almost thirty years after his death and spread the word far and wide. Mendel’s work shows us that genius can emerge from the most unlikely quarters; one wonders how rapidly his work might have been disseminated had the Internet been around.

The baton of the gene was next picked up by Francis Galton, Darwin’s cousin. Galton was the father of eugenics. Eugenics has now acquired a bad reputation, but Galton was a polymath who made important contributions to science by introducing statistics and measurements in the study of genetic differences. Many of the early eugenicists subscribed to the racial theories that were common in those days; many of them were well intended if patronizing, seeking to ‘improve the weak’, but they did not see the ominous slippery slope which they were on. Sadly their ideas fed into the unfortunate history of eugenics in America and Europe. Eugenics was enthusiastically supported in the United States; Mukherjee discusses the infamous Supreme Court case in which Oliver Wendell Holmes sanctioned the forced sterilization of an unfortunate woman named Carrie Buck by proclaiming, “Three generations of imbeciles are enough”. Another misuse of genetics was by Trofim Lysenko who tried to use Lamarck’s theories of acquired characteristics in doomed agricultural campaigns in Stalinist Russia; as an absurd example, he tried to “re educate” wheat using “shock therapy”. The horrific racial depredations of the Nazis which the narrative documents in some detail of course “put the ultimate mark of shame” on eugenics.

The book then moves on to Thomas Hunt Morgan’s very important experiments on fruit flies. Morgan and his colleagues found a potent tool to study gene propagation in naturally occurring mutations. Mutations in specific genes (for instance ones causing changes in eye color) allowed them to track the flow of genetic material through several generations. Not only did they make the crucial discovery that genes lie on chromosomes, but they also discovered that genes could be inherited (and also segregated) in groups rather than by themselves. Mukherjee also has an eye for historical detail; for example, right at the time that Morgan was experimenting on flies, Russia was experimenting with a bloody revolution. This coincidence gives Mukherjee an opening to discuss hemophilia in the Russian royal family – a genetically inherited disease. A parallel discussion talks about the fusion of Darwin's and Mendel’s ideas by Ronald Fisher, Theodosius Dobzhansky and others into a modern theory of genetics supported by statistical reasoning in the 40s – what’s called the Modern Synthesis.

Morgan and others’ work paved the way to recognizing that the gene is not just some abstract, ether-like ghost which transmits itself into the next generation but a material entity. That material entity was called DNA. The scientists most important for recognizing this fact were Frederick Griffiths and Oswald Avery and Mukherjee tells their story well; however I would have appreciated a fuller account of Friedrich Miescher who discovered DNA in pus bandages from soldiers. Griffiths showed that DNA can be responsible for converting non-virulent bacteria to virulent ones; Avery showed that it is a distinct molecule separate from protein (a lot of people believed that proteins with their functional significance were the hereditary material).

All these events set the stage for the golden age of molecular biology, the deciphering of the structure of DNA by James Watson (to whom the quote in the title is attributed), Francis Crick, Rosalind Franklin and others. Many of these pioneers were inspired by a little book by physicist Erwin Schrodinger which argued that the gene could be understood using precise principles of physics and chemistry; his arguments turned biology into a reductionist science. Mukherjee’s account of this seminal discovery is crisp and vivid. He documents Franklin’s struggles and unfair treatment as well as Watson and Crick’s do-what-it-takes attitude to use all possible information to crack the DNA puzzle. As a woman in a man’s establishment Franklin was in turn patronized and sidelined, but unlike Watson and Crick she was averse to building models and applying the principles of chemistry to the problem, two traits that were key to the duo’s success.

The structure of DNA of course inaugurated one of the most sparkling periods in the history of intellectual thought since it immediately suggested an exact mechanism for copying the hereditary material as well as a link between DNA and proteins which are the workhorses of life. The major thread following from DNA to protein was the cracking of the genetic code which specifies a correspondence between nucleotides on a gene and the amino acids of a protein: the guiding philosophers in this effort were Francis Crick and Sydney Brenner. A parallel thread follows the crucial work of the French biologists Francois Jacob and Jacques Monod - both of whom had fought in the French resistance during World War 2 - in establishing the mechanism of gene regulation. All these developments laid the foundation for our modern era of genetic engineering.

The book devotes a great deal of space to this foundation and does so with verve and authority. It talks about early efforts to sequence the gene at Harvard and Cambridge and describes the founding of Genentech, the first company to exploit the new technology which pioneered many uses of genes for producing drugs and hormones: much of this important work was done with phages, viruses which infect bacteria. There is also an important foray into using genetics to understand embryology and human development, a topic with ponderous implications for our future. With the new technology also came new moral issues, as exemplified by the 1975 Asilomar conference which tried to hammer out agreements for the responsible use of genetic engineering. I am glad Mukherjee emphasizes these events, since their importance is only going to grow as genetic technology becomes more widespread and accessible.

These early efforts exploded on to the stage when the Human Genome Project (HGP) was announced, and that’s where the first part of the book roughly ends. Beginning with the HGP, the second part mainly focuses on the medical history and implications of the gene. Mukherjee’s discussion of the HGP focuses mainly on the rivalries between the scientists and the competing efforts led by Francis Collins of the NIH and Craig Venter, the maverick scientist who broke off and started his own company. This discussion is somewhat brief but it culminates in the announcement of the map of the human genome at the White House in 2000. It is clear now that this “map” was no more than a listing of components; we still have to understand what the components mean. Part of that lake of ignorance was revealed by the discovery of so-called ‘epigenetic’ elements that modify not the basic sequence of DNA but the way it’s expressed. Epigenetics is an as yet ill-understood mix of gene and environment which the book describes in some detail. It’s worth noting that Mukherjee’s discussion of epigenetics has faced some criticism lately, especially based on his article on the topic in the New Yorker.

The book then talks about early successes in correlating genes with illness that came with the advent of the human genome and epigenome; genetics has been very useful in finding determinants and drugs for diseases like sickle cell anemia, childhood leukemia, breast cancer and cystic fibrosis. Mukherjee especially has an excellent account of Nancy Wexler, the discoverer of the gene causing Huntington’s disease, whose search for its origins led her to families stricken with the malady in remote parts of Venezuela. While such diseases have clear genetic determinants, as Mukherjee expounds upon at length, genetic causes for diseases like cancer, diabetes and especially the mental illness which plagues members of the author’s family are woefully ill-understood, largely because they are multifactorial and suffer from weakly correlated markers. We have a long way to go before the majority of human diseases can be treated using gene-based treatment. In its latter half the book also describes attempts to link genes to homosexuality, race, IQ, temperament and gender identity. The basic verdict is that while there is undoubtedly a genetic component to all these factors, the complex interplay between genes and environment means that it’s very difficult currently to tease apart influences from the two. More research is clearly needed.

The last part of the book focuses on some cutting edge research on genetics that’s uncovering both potent tools for precise gene engineering as well as deep insights into human evolution. A notable section of the book is devoted to the recent discovery that Neanderthals and humans most likely interbred. Transgenic organisms, stem cells and gene therapy also get a healthy review, and the author talks about successes and failures in these areas (an account of a gene therapy trial gone wrong is poignant and rattling) as well as ethical and political questions which they raise. Finally, a new technology called CRISPR which has taken the world of science by storm gets an honorary mention: by promising to edit and propagate genes with unprecedented precision - even in the germ line - CRISPR has resurrected all the angels and demons from the history of genetics. What we decide about technologies like CRISPR today will impact what our children do tomorrow. The clock is ticking.

In a project as ambitious as this there are bound to be a few gaps. Some of the gaps left me a bit befuddled though. There are a few minor scientific infelicities: for instance Linus Pauling’s structure of DNA was not really flawed because of a lack of magnesium ions but mainly because it sported a form of the phosphate groups that wouldn’t exist at the marginally alkaline pH of the human body. The book’s treatment of the genetic code leaves out some key exciting moments, such as when a scientific bombshell from biochemist Marshall Nirenberg disrupted a major meeting in the former Soviet Union. I also kept wondering how any discussion of DNA’s history could omit the famous Meselson-Stahl experiment; this experiment which very elegantly illuminated the central feature of DNA replication has been called “the most beautiful experiment in biology”. Similarly I could see no mention of Barbara McClintock whose experiments on ‘jumping genes’ were critical in understanding how genes can be turned on and off. I was also surprised to find few details on a technique called PCR without which modern genetic research would be virtually impossible: both PCR and its inventor Kary Mullis have a colorful history that would have been worth including. Similarly, details of cutting-edge sequencing techniques which have outpaced Moore’s Law are also largely omitted. I understand that a 600 page history cannot include every single scientific detail, but some of these omissions seem to me to be too important to be left out.

More broadly, there is no discussion of the pros and cons of using DNA to convict criminals: that would have made for a compelling human interest story. Nor is there much exploration of using gene sequences to illuminate the ‘tree of life’ which Darwin tantalizingly pulled the veil back on: in general I would have appreciated a bigger discussion of how DNA connects us to all living creatures. There are likewise no accounts of some of the fascinating applications of DNA in archaeological investigations. Finally, and this is not his fault, the author suffers from the natural disadvantage of not being able to interview many of the pioneers of molecular biology since they aren’t around any more (fortunately, Horace Freeland Judson’s superb “The Eighth Day of Creation” fills this gap: Judson got to interview almost every one of them for his book). This makes his account of science sound a bit more linear than the messy, human process that it is.

The volume ends by contemplating some philosophical questions: What are the moral and societal implications of being able to engineer genomes even in the fetal stage? How do we control the evils to which genetic technology can be put? What is natural and what isn’t in the age of the artificial gene? How do we balance the relentless, almost inevitable pace of science with the human quest for responsible conduct, dignity and equality? Mukherjee leaves us with a picture of these questions as well as one of his family and their shared burden of mental illness: a mirage searching for realization, a sea of questions looking for a tiny boat filled with answers.

Overall I found “The Gene: An Intimate History” to be beautifully written with a literary flair, and in spite of the omissions, the parts of genetic history and medicine which it does discuss are important and instructive. Its human stories are poignant, its lessons for the future pregnant with pitfalls and possibilities. Its sweeping profile of life’s innermost secrets could not help but remind me of a Japanese proverb quoted by physicist Richard Feynman: “To every man is given the key to the gates of heaven. The same key opens the gates of hell.” The gene is the ultimate key of this kind, and Mukherjee’s book explores its fine contours in all their glory and tragedy. We have a choice in deciding which of these contours we want to follow.

28 of 28 people found the following review helpful.
The author's biggest success is in weaving a beautiful narrative. Starting with the emotionally-charged personal links to ...
By NJ
Gene is a must-read history book on genetics. Many accounts have been penned on Relativity and Quantum Mechanics, for instance, to make their importance known to the non-professionals. Gene fills the void for the equally important science of Genetics.

The author's biggest success is in weaving a beautiful narrative. Starting with the emotionally-charged personal links to the field to the frequent detailing of personalities of or anecdotes involving famous scientists, the subject is kept 'human'. There are abundant scientific notions to satisfy any reader picking up the book to understand the real subject matter, but not in the general bland fashion of studies-and-conclusions that tend to lose many a lay people.

The book also excels because of the simplicity with which countless exotic concepts are explained. From the notions of introns and exons to the polygenic nature of most phenotypes, the feedback from environment to gene mutation and the massive role played by non-gene factors in most our traits, the author uncovers a staggering number of interesting findings in a highly understandable manner.

Amid all this, the author keeps the focus on various moral and ethical issues. The narrative is laced with historic episodes of all kinds to emphasise the criticality of the questions confronting us as we make more scientific progress. For example, the book beautifully explains the dangers of genetic modification - which tantamounts to replacing natural selection with human selection. As professionals or parents seek to weed out certain deformities, there are genuine risks of us eliminating some important evolutionary traits mainly out of ignorance of how genes really work at this stage but also out of their possible other utilities in long future.

The biggest flaw of the book is insufficient focus on latest developments and near absence of what this science is capable of solving in coming decades. The optimists out there expect congenitally blind people to see and cancers all cured. Some expect us to be able to grow a third arm if we so choose or re-create a dinosaur in a century or so. Genetics is combined with nanotechnology, cryonics, robotics etc by many fantasizers to come up with even more fanciful theories. The author could have added a chapter or two to discuss gene therapy and other recent experiments to complete the excellent work further.

That said, a remarkable book in all aspects.

3 of 3 people found the following review helpful.
A six star book
By Brian Hunt
Dr. Mukherjee’s earlier book, The Emperor of All Maladies, a book on cancer, is on my list of all-time top ten books. His new book is also at or close to the same level: It is a six star book on a scale of one to five. Dr. Mukherjee writes beautifully and with extraordinary clarity on very difficult technical subjects, moving effortlessly from complex, detailed biochemical processes to enormous ethical issues affecting our very future as a species.

This book is a masterful story of the history of genetics, starting from Mendel and Darwin right up to the latest gene modification processes; it is the clearest and most comprehensive account that I have read. But it is much more because Dr. Mukherjee introduces us to human dramas involving both researchers and patients. He also sets out the moral issues of our growing power to change the genomes not only of living people and embryos but also of descendants who have yet to be conceived.

Woven through the book is the personal story of Dr. Mukherjee’s family, which has a history of schizophrenia. Two of Dr. Mukherjee’s uncles and one of his first cousins suffered the devastating effects of schizophrenia and he lives with the possibility that he, too, may someday be struck down and/or have passed the disruptive genes on to his children.

This is not a lightweight book but I found it easy to read, thanks to the elegance of the writing, and totally gripping. As Dr. Mukherjee makes clear, we stand on the brink of a genetic future that has great promise and also great peril. This is an important book and deserves to be widely read.

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Thirty One Days of Prayer for the Dreamer and the Doer, by Jenn Sprinkle, Kelly Rucker

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Thirty One Days of Prayer for the Dreamer and the Doer, by Jenn Sprinkle, Kelly Rucker

We are dreamers & doers - ambitious business owners - we love hard - try to 'do-it-all' and grow weary in the process. We need each other to lean on and to love on. More and more women are weaving their stories, their burdens and their God-given gifts into big dreams, intentional businesses and God's work. Our prayer for this book is to keep you tethered to your faith and to the Lord, who without His saving grace, all dreaming and doing is in vain.

Curated by The {Well} Studio and written by an inspiring group of dreamers and doers, the prayers and scripture that fill these pages are written to accompany you on this the journey of brilliant dreams and scary risks, weary struggles and joyful success, inspiring ideas and fears of failure....all in light of how God has created us to be and to do all things well....not perfectly, but {well}.

PRAYERS INCLUDE: Faith, Prayer, God's Word, Grace, Identity, Freedom, Seasons, Motherhood, Marriage, Comparison, Fears, Simplicity, Rest, the Dreams of our Spouses and Children, Influence, Business, Finances, Social Media, Goals, Creativity, Simplicity, Ministry, Dreams, Authenticity, Fears, Productivity, Branding, Health, Loving {well}, Collaborating, Confidence, Calling + Purpose.

  • Sales Rank: #306369 in eBooks
  • Published on: 2015-02-25
  • Released on: 2015-02-25
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10 of 10 people found the following review helpful.
Be encouraged, inspired, and comforted.
By Stephanie Kilper
Praying and reading God's word are things that I do not do with any regularity. I avoid these things out of fear. Fear of doing it wrong, of being vulnerable, of the changes that letting God really, truly into my life and heart will bring. This book took me gently by the hand and heart and reminded me that I'm going to be okay. It gave me a safe place to open myself up to Christ's love and leading. I feel encouraged and empowered. This book will take you through vulnerable and uncomfortable topics and, with grace and care, give you the space to open yourself up to becoming the beautiful, brave, and bold woman that God always knew you could be. Now it's time to believe in you. You can do it, sweet one.

7 of 7 people found the following review helpful.
The struggle is real y'all
By Daphne Bamburg
The battle between dreaming and doing is one with which I'm all too familiar. I love the idea of a resource that encourages and inspires women to slow down and pray to the God of the universe who supplies both the dream and the power to do. May God-inspired dreams come true for our great joy and His great glory as a result of this book.

3 of 3 people found the following review helpful.
This devotional book is answered prayer!
By Michelle McKinney
As I read, I thought, “How did they know what I was going through?” Because we are often building and dreaming in isolation, it can feel like you’re the only one but you’re not. I celebrate the transparency of the authors. As a business owner who walks women through discovering and building their God-given dreams, I know these prayers will be a resource for all of us as we juggle many roles. Along with my Bible, I’ll continue to run to these prayers when I’m feeling empty and even when my cup is full.

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